Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivationArticle Published on 2022-09-142022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] activated Activation acute respiratory syndrome Adenovirus aggravate Aggravated alleviate complement Complement pathway contribute coronavirus Coronaviruses expressing highly pathogenic human coronaviruses Hyperactivation in vitro in vivo Inflammation inflammatory lung injury Inflammatory response Interaction lectin pathway Lung injury MASP-2 mechanism MERS-CoV mice N protein Pathogenesis pathogenic coronavirus Pneumonia respiratory syndrome coronavirus resulting SARS-CoV SARS-CoV-2 SARS-CoV-2-infected patients serine protease significantly suggested the N protein Therapeutic approach These data [DOI] 10.1038/s41392-022-01133-5 PMC 바로가기
Lower brachial artery flow-mediated dilation is associated with a worse prognosis and more lung parenchymal involvement in Covid-19: Prospective observational studyObservational Study Published on 2022-08-192022-10-05 Journal: Medicine [Category] 임상, [키워드] acute respiratory disease acute respiratory syndrome angiotensin-converting enzyme 2 Biochemical parameters brachial caused Coagulopathy coronavirus disease Coronavirus-2 cutoff point D-dimer Diagnosis died discharged disease Endothelial dysfunction endothelial function evaluate evaluated ferritin Hospitalized ICU ICU admission ICU patient intensive care investigated lactate dehydrogenase Lower lung lung involvement lung parenchyma moderate Mortality mortality rate multicenter negative correlation pandemic parenchymal pathogenic coronavirus patients patients hospitalized Prognosis Prospective prospective observational study receptor resulting risk factor shown significantly lower the patient vascular inflammation virus White blood cell worse prognosis [DOI] 10.1097/MD.0000000000030001 PMC 바로가기 [Article Type] Observational Study
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species병원성 코로나바이러스 종에 대한 다중 LNP-mRNA 백신 접종Article Published on 2022-08-022022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated adaptive animal models antibody antibody immunity Antibody Response antigen-specific antibody B cell coronavirus Coronavirus vaccines COVID-19 vaccine CP: Immunology cross-reactivity Delta develop Differential gene expression effective feasibility immune immune cells Immune profile immune response immunology increase in induce MERS-CoV mRNA mRNA vaccine multiplexed vaccination multispecies coronavirus vaccine offer pathogenic coronavirus profile responses responses against RNA sequencing SARS-CoV SARS-CoV-2 sequential vaccination significantly single-cell single-cell profiling systems immunology. Transcriptome triplex vaccination vaccination schedule vaccine candidate [DOI] 10.1016/j.celrep.2022.111160 PMC 바로가기 [Article Type] Article
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNA. siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease Research Published on 2022-05-262022-10-05 Journal: NPJ Vaccines [Category] 변종, 유전자 메커니즘, [키워드] antibody Antigen antigenicity BALB/c mice Combination comparable convalescent plasma COVID-19 cases COVID-19 pandemic defined disease effective vaccine elevated elicited Emergency use Endpoint facilitate highlight immunization immunized immunogenic infected patients Infection Live virus Lung infection MERS-CoV neutralization titer neutralizing antibody responses Particle pathogenic coronavirus physiochemical property platform PLP PROTECT Protein provide RBD RBD-specific IgG robust SARS-CoV-2 SARS-CoV-2 variant serum the receptor-binding domain the United State These data Vaccine Vaccines [DOI] 10.1038/s41541-022-00481-1 [Article Type] Research
Basic virology of SARS-CoV 2SARS-CoV 2의 기본 바이러스학Review Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] Coronavirus, COVID19(2023년), SARS, 치료법, [키워드] 229E acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus basic bats bind cats Cell cell surface cellular membrane Characteristics clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID 19 COVID-19 disease envelope Exocytosis followed by fusion Genome genomic genomic RNA global public health helical symmetry HKU1 host cell host cell cytosol hosts human coronaviruses humans Immunological response Infection mammalian membrane MERS MERS-CoV Mild NL63 nucleocapsid OC43 pandemic Pathogenesis pathogenic pathogenic coronavirus positive Protein receptor Receptor binding released RNA genome RNA synthesis S protein SARS CoV SARS CoV-2 SARS-CoV 2 SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread structural proteins the S protein translation transported Vesicle vesicles viral genome viral genomic RNA viral replication virion virions Virology Virology. virus [DOI] 10.1016/j.ijmmb.2022.02.005 PMC 바로가기 [Article Type] Review
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation17개의 SARS-CoV-2 단백질의 근위 프로테옴은 항바이러스 신호 전달 및 숙주 번역을 방해합니다.Research Article Published on 2021-10-012022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation antiviral signaling association atlas Card cleavage complex coronavirus Coronaviruses COVID-19 severity CWC22 database Factor FANCD2 Fluorescence functional Host host protein host proteins human cell human protein identify IFNB1 Impact inhibited inhibitor innate immune interferon signaling M protein MAVS membranes nsp1 nsp5 ORF6 Pathogenesis pathogenic coronavirus pathogenic mechanism pathogenic mechanisms pathogenicity peptide peptide sequences promote promoter protease Protein protein translation Proteins proteome proteomics proximal public health threat regulator Regulatory resource RIG-I SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral sequence Signaling subcellular target the SARS-CoV-2 translation translation initiation Transport TRIM4 variant Viral Viral protein Viral proteins [DOI] 10.1371/journal.ppat.1009412 PMC 바로가기 [Article Type] Research Article
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19Research Article Published on 2021-08-032022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome Ad5-hACE2 airway epithelia angiotensin-converting enzyme 2 bind Calu-3 camostat Camostat mesylate caused Cell cell line cleaved coronavirus coronavirus disease COVID-19 disease pathogenesis entry of SARS-CoV-2 epithelia exhibiting greater hACE2 host cell human ACE2 in vivo Infection inhibit inhibitors initiate intranasal K18 K18-hACE2 limit lung tissue membrane fusion MERS-CoV mice Middle East Model morbidity and mortality Mortality mouse Mouse models nafamostat pandemic pathogenic coronavirus preclinical drug studies primary human airway Prophylactic protease Protease inhibitor protease TMPRSS2 Protective pulmonary receptor reduced respiratory syndrome coronavirus respiratory tract SARS-CoV-2 SARS-COV-2 infection serine protease serine protease inhibitors significantly Spike protein tested the spike protein TMPRSS2 transgenic mice Treatment viral burden weight loss [DOI] 10.1128/mBio.00970-21 PMC 바로가기 [Article Type] Research Article
The Pathogenic Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Possible Mechanisms for Immune Evasion?Immunology Published on 2021-07-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome caused coronavirus coronavirus 2 death Epidemiology event feature global public health Immune escape immune evasion Interaction mechanism pathogenic pathogenic coronavirus pathogenic features reported respiratory S protein SARS-CoV-2 transmitted virus [DOI] 10.3389/fimmu.2021.693579 PMC 바로가기 [Article Type] Immunology
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryTMPRSS2 발현을 위한 고처리량 스크린으로 SARS-CoV-2 진입을 제한할 수 있는 FDA 승인 화합물 식별Article Published on 2021-06-232022-09-10 Journal: Nature Communications [Category] MERS, SARS, 비임상, [키워드] 2019-nCoV ACE2 breath Cell cell entry cell surface receptor clinical trial Compound compounds Concentration concentrations coronavirus COVID-19 disease COVID-19 infection DCAF1 DDB1 Degradation dependent on drug E3 ubiquitin ligase Effect entry of SARS-CoV-2 epithelial cells expression global pandemic halofuginone help High-throughput screening homoharringtonine Host host protease host proteases human clinical trial human clinical trials Human plasma identify in vitro library limit lung epithelial cell modulate pathogenic coronavirus pharmacokinetic data proteasome Protein reduce reducing responsible SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 glycoprotein SARS-COV-2 infection Screen Serine serine protease serine protease TMPRSS2 small molecule Small molecules spike stability surface expression surface receptor the cell TMPRSS2 TMPRSS2 expression TMPRSS2 level TMPRSS2 levels TMPRSS2 protein [DOI] 10.1038/s41467-021-24156-y PMC 바로가기 [Article Type] Article